Signaling dynamics and embryonic development

Signaling dynamics and embryonic development

During embryonic development, signaling molecules convey positional information within the embryo and direct cells to adopt particular fates. A crucial question is how do the receiving cells of the embryo interpret these signals? While most work on this issue has focused on the biochemical and genetic dissection of the molecular circuitry of signal transduction, understanding signaling as a dyn...

Wnt Signaling in Embryonic Development

Researchers studying the Wnt pathway frequently like to joke that ‘Wnts do everything’, and that this fact keeps us all in business. Over time, this claim has become less facetious, as the number of known roles for Wnt signaling has grown rapidly. Following on from the first identified functions of Wnts in embryonic tissue patterning and cell proliferation, these signals and their multiple down...

Editorial: Signaling Pathways in Embryonic Development

Purinergic Signaling during Rat Embryonic Development

Adenosine 5’-triphosphate (ATP) has been shown to be an important extracellular signaling molecule that mediates various physiological activities via the P2 (P2X and P2Y) receptors. However, information on the expression patterns of the P2 receptors during mammalian embryogenesis is limited. We therefore examined the expression patterns of different P2 receptor subtypes in rat embryos. In the h...

Notch Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling.

Lung development is mediated by assorted signaling proteins and orchestrated by complex mesenchymal-epithelial interactions. Notch signaling is an evolutionarily conserved cell-cell communication mechanism that exhibits a pivotal role in lung development. Notably, both aberrant expression and loss of regulation of Notch signaling are critically linked to the pathogenesis of various lung disease...